Basic Information

Symbol
TCF7L1
RNA class
mRNA
Alias
Transcription Factor 7 Like 1 Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) HMG Box Transcription Factor 3 Transcription Factor 7-Like 1 TCF3 TCF-3
Location (GRCh38)
2:85133392-85310388
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_031283.3
Sequence length
2985.0 nt
GC content
0.6137

Transcripts

ID Sequence Length GC content
NM_031283.3 NCBI
GCUCGCCCCUCCCCGGCGGGCCAGGGGCUGGGACGCCCCGGCGGAGCAG… 2985 nt 0.6137
Summary

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

Forensic Context

A study in mice demonstrated that the transcription factor TCF7L1 was enriched in serotonergic neurons during the post-addiction phase and in dopaminergic neurons during the pre-addiction phase of nicotine self-administration, as identified through single-nucleus RNA sequencing and SCENIC regulatory network analysis [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].