Basic Information

Symbol
TCF7L2
RNA class
mRNA
Alias
Transcription Factor 7 Like 2 TCF-4 TCF4 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) T-Cell-Specific Transcription Factor 4 HMG Box Transcription Factor 4 Transcription Factor 7-Like 2 T-Cell Factor 4 HTCF-4
Location (GRCh38)
10:112950205-113167678
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001367943.1
Sequence length
4076.0 nt
GC content
0.4558

Transcripts

ID Sequence Length GC content
NM_001198530.2 NCBI
GUCAAUAAUCUCCGCUCCCAGACUACUCCGUUCCUCCGGAUUUCGAUCC… 3781 nt 0.4509
NM_001198531.2 NCBI
GUCAAUAAUCUCCGCUCCCAGACUACUCCGUUCCUCCGGAUUUCGAUCC… 3952 nt 0.4542
NM_001349870.2 NCBI
AGAUAAAGUGCCUGCCUCCUGCACUCGGUUGAUCAUUUUCCCUCAUGGC… 3756 nt 0.4385
NM_001349871.1 NCBI
AUUGUGCUCUUCCCUAUCAAGCGAGAUAAUUCUGUGAAUGGAACUGUGC… 3288 nt 0.4556
NM_001363501.2 NCBI
GUCAAUAAUCUCCGCUCCCAGACUACUCCGUUCCUCCGGAUUUCGAUCC… 4003 nt 0.4539
NM_001367943.1 NCBI
GUCAAUAAUCUCCGCUCCCAGACUACUCCGUUCCUCCGGAUUUCGAUCC… 4076 nt 0.4558
NM_030756.5 NCBI
GUCAAUAAUCUCCGCUCCCAGACUACUCCGUUCCUCCGGAUUUCGAUCC… 4007 nt 0.4557
Showing 11 to 17 of 17 entries
Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Forensic Context

A study in mice demonstrated that the TCF7L2 is a predicted upstream regulator of genes in Patterns B and C (cocaine self-administration plus withdrawal) in the brain's reward circuitry [Walker et al. DOI:10.1016/J.Biopsych.2018.04.009]. In a separate study using mouse embryonic neural stem cells, ethanol exposure during differentiation was found to downregulate the TCF7L2 as part of the Wnt signaling pathway [Mandal et al. DOI:10.1007/S11033-015-3862-1].