Basic Information

Symbol
TDRD1
RNA class
mRNA
Alias
Tudor Domain Containing 1 CT41.1 Cancer/Testis Antigen 41.1 Tudor Domain-Containing Protein 1 Testicular Tissue Protein Li 193
Location (GRCh38)
10:114179270-114232666
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001395205.1
Sequence length
8149.0 nt
GC content
0.3971

Transcripts

ID Sequence Length GC content
NM_001385372.1 NCBI
GCACUGGGGAUUGGAGGCGAGGGAAGUGCAGGGCGCAUCCCAGGCGGCA… 4539 nt 0.4047
NM_001395205.1 NCBI
AGUCGCCAUCACCGCCAGACCGCAGAGACAGGUUCGGAUCCGCGGUCCU… 8149 nt 0.3971
NM_198795.2 NCBI
GCACUGGGGAUUGGAGGCGAGGGAAGUGCAGGGCGCAUCCCAGGCGGCA… 4855 nt 0.3988
Showing 11 to 13 of 13 entries
Summary

This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]

Forensic Context

A study in humans identified the TDRD1 as a potential biomarker for sepsis diagnosis, where it was found to be lowly expressed in the sepsis group based on RNA sequencing data and its mRNA expression pattern was consistent with its corresponding protein according to nine-quadrant analysis [Wang et al. DOI:10.2147/IDR.S380137].