Basic Information

Symbol
TECR
RNA class
mRNA
Alias
Trans-2,3-Enoyl-CoA Reductase TER Very-Long-Chain Enoyl-CoA Reductase MRT14 GPSN2 SC2 Synaptic Glycoprotein SC2 Glycoprotein, Synaptic 2 Epididymis Secretory Sperm Binding Protein EC 1.3.1.93 EC 1.3.1.38 EC 1.3.1
Location (GRCh38)
19:14517085-14565988
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_138501.6
Sequence length
1139.0 nt
GC content
0.6049

Transcripts

ID Sequence Length GC content
NM_001321170.1 NCBI
GCGGCCUGGAGGGGCGGGGCGGACGCAGAGCCGCGUUUAGUCUAUCGCU… 1261 nt 0.5948
NM_138501.6 NCBI
GUUUAGUCUAUCGCUGCGGUUGCGAGCGCUGUAGGGAGCCUGUGCUGUG… 1139 nt 0.6049
Summary

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

Forensic Context

A study in rats demonstrated that the TECR was downregulated in spinal cord tissue following contusive injury, including at 7 and 35 days post-injury within the lesion epicenter [Aimone et al. DOI:10.1016/j.expneurol.2004.05.042].