Basic Information

Symbol
TEK
RNA class
mRNA
Alias
TEK Receptor Tyrosine Kinase VMCM1 TIE2 Angiopoietin-1 Receptor CD202b TIE-2 VMCM Tyrosine Kinase With Ig And EGF Homology Domains-2 Tunica Interna Endothelial Cell Kinase Tyrosine-Protein Kinase Receptor TIE-2 Tyrosine-Protein Kinase Receptor TEK TEK Tyrosine Kinase, Endothelial Endothelial Tyrosine Kinase EC 2.7.10.1 Venous Malformations, Multiple Cutaneous And Mucosal CD202b Antigen EC 2.7.10 P140 TEK GLC3E HTIE2
Location (GRCh38)
9:27109030-27232092
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden death from CNS diseases Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000459.5
Sequence length
4683.0 nt
GC content
0.4512

Transcripts

ID Sequence Length GC content
NM_000459.5 NCBI
CUCUGCCCCUACAGCAGCAGCAAAAGCAGCAGCAGAAGCAACAGCAACA… 4683 nt 0.4512
NM_001290077.1 NCBI
UUAUUCUCAGUUUCCCGCCUAUGAGAGGAUACCCCUAUUGUUUCUGAAA… 4658 nt 0.4472
NM_001290078.1 NCBI
UUAUUCUCAGUUUCCCGCCUAUGAGAGGAUACCCCUAUUGUUUCUGAAA… 4343 nt 0.4449
NM_001375475.1 NCBI
GCUGUUCCUUCUUGCCUCUAACUUGUAAACAAGACGUAGUAGGACGAUG… 4455 nt 0.4503
NM_001375476.1 NCBI
GCUGUUCCUUCUUGCCUCUAACUUGUAAACAAGACGUAGUAGGACGAUG… 4326 nt 0.4475
Summary

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] CIViC Summary for TEK Gene

Forensic Context

A study in mice demonstrated that juvenile animals exhibit reduced cortical lesion volume, cell death, and behavioral deficits following controlled cortical impact (CCI) traumatic brain injury compared to adults, correlating with enhanced restoration of cerebral blood flow, reduced blood-brain barrier (BBB) disruption, and increased perilesional vessel density [Brickler et al. DOI:10.1523/JNEUROSCI.0914-18.2018]. A study in rats demonstrated that the TEK mRNA was up-regulated in a blast intensity- and time-dependent manner following low-level blast wave exposure, correlating with histological evidence of vascular injury and thrombosis [Balaban et al. DOI:10.1016/j.jneumeth.2016.02.001].