Basic Information

Symbol
TERF2IP
RNA class
mRNA
Alias
TERF2 Interacting Protein RAP1 Telomeric Repeat-Binding Factor 2-Interacting Protein 1 Dopamine Receptor-Interacting Protein 5 TERF2-Interacting Telomeric Protein 1 Repressor/Activator Protein 1 Homolog DRIP5 Telomeric Repeat Binding Factor 2, Interacting Protein TRF2-Interacting Telomeric RAP1 Protein TRF2-Interacting Telomeric Protein 1 RAP1 Homolog HRap1
Location (GRCh38)
16:75647765-75761872
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018975.4
Sequence length
2131.0 nt
GC content
0.5016

Transcripts

ID Sequence Length GC content
NM_018975.4 NCBI
AGUGCUGCGCUUCGCGGCAGAGGCGUCUGCGGUGACAGCUCAGUCAGUU… 2131 nt 0.5016
Summary

Enables G-rich strand telomeric DNA binding activity and phosphatase binding activity. Involved in several processes, including positive regulation of non-canonical NF-kappaB signal transduction; protection from non-homologous end joining at telomere; and regulation of primary metabolic process. Located in chromosome, telomeric region; cytoplasm; and nuclear body. Part of shelterin complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human pediatric sepsis patients identified the TERF2IP as exhibiting decreased polyadenylation in viral compared to bacterial infection samples, classifying it among candidate genes with differential poly(A) tail length variation [He et al. DOI:10.1186/s12879-025-11078-z].