Basic Information

Symbol
TET1
RNA class
mRNA
Alias
Tet Methylcytosine Dioxygenase 1 LCX Leukemia-Associated Protein With A CXXC Domain BA119F7.1 KIAA1676 CXXC6 Ten-Eleven Translocation 1 Gene Protein Methylcytosine Dioxygenase TET1 CXXC-Type Zinc Finger Protein 6 CXXC Zinc Finger 6 Tet Oncogene 1 Ten-Eleven Translocation 1 Ten-Eleven Translocation-1 CXXC Finger 6 EC 1.14.11.80 EC 1.14.11.N2
Location (GRCh38)
10:68560310-68694586
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_030625.3
Sequence length
9612.0 nt
GC content
0.4207

Transcripts

ID Sequence Length GC content
NM_001406365.1 NCBI
ACUCCCUGAGGUCUGUCCUGGGGAGACACUGCUGCUCCGGGGGGCUGAC… 9699 nt 0.4208
NM_001406367.1 NCBI
AUCCUUUGUCUAGGAAGGGCUAGGCUGAGAAGAUCACUUUGGAGUUGCU… 7663 nt 0.3951
NM_001406368.1 NCBI
AUGCAGACCUGCCCUCGGAACCGCCAAGAGGUUACUAAUCAGGAAGGCU… 7440 nt 0.3968
NM_001406369.1 NCBI
AUCCUUUGUCUAGGAAGGGCUAGGCUGAGAAGAUCACUUUGGAGUUGCU… 7549 nt 0.3963
NM_001406370.1 NCBI
AUCCUUUGUCUAGGAAGGGCUAGGCUGAGAAGAUCACUUUGGAGUUGCU… 7553 nt 0.3965
NM_001406371.1 NCBI
AUGCAGACCUGCCCUCGGAACCGCCAAGAGGUUACUAAUCAGGAAGGCU… 7353 nt 0.3964
NM_001406372.1 NCBI
AUCCUUUGUCUAGGAAGGGCUAGGCUGAGAAGAUCACUUUGGAGUUGCU… 7466 nt 0.3962
NM_001406373.1 NCBI
ACUCCCUGAGGUCUGUCCUGGGGAGACACUGCUGCUCCGGGGGGCUGAC… 7206 nt 0.4291
NM_001406374.1 NCBI
ACUCCCUGAGGUCUGUCCUGGGGAGACACUGCUGCUCCGGGGGGCUGAC… 7119 nt 0.4291
NM_001406375.1 NCBI
AUGCAGACCUGCCCUCGGAACCGCCAAGAGGUUACUAAUCAGGAAGGCU… 5132 nt 0.3979
Showing 1 to 10 of 12 entries
Summary

DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015] CIViC Summary for TET1 Gene

Forensic Context

A study in mice and postmortem human brain demonstrated that chronic cocaine exposure decreases the TET1 in the nucleus accumbens, and its downregulation potentiates behavioral responses to cocaine [Nestler DOI:10.1016/J.Neuropharm.2013.04.004].