Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| ACAGAAGCGAGUCCGACUGUGCUCGCUGCUCAGCGCCGCACCCGGAAGA… | 20166 nt | 0.4177 | |
| AGCUGCAGCAGAAGAGCGGAAAUGUCAAACGUGGAGGGCUGUGCCUGGC… | 21134 nt | 0.4200 | |
| ACAGAAGCGAGUCCGACUGUGCUCGCUGCUCAGCGCCGCACCCGGAAGA… | 19993 nt | 0.4167 |
Summary
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] CIViC Summary for TF Gene
Forensic Context
A study in humans demonstrated that short-term overfeeding induced differential expression of 45 genes in abdominal subcutaneous adipose tissue, with six genes showing a significant interaction between adiposity status and treatment [Shea et al. DOI:10.3945/ajcn.2008.25970].