Basic Information

Symbol
TFPI
RNA class
mRNA
Alias
Tissue Factor Pathway Inhibitor TFPI1 EPI Extrinsic Pathway Inhibitor LACI TFI Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) Lipoprotein-Associated Coagulation Inhibitor Anti-Convertin
Location (GRCh38)
2:187463823-187565846
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006287.6
Sequence length
3859.0 nt
GC content
0.3467

Transcripts

ID Sequence Length GC content
NM_001032281.4 NCBI
AGACAGCAGCGACUUUAGGCUGGAUAAUAGUCAAAUUCUUACCUCGCUC… 1092 nt 0.3755
NM_001318941.3 NCBI
AGACAGCAGCGACUUUAGGCUGGAUAAUAGUCAAAUUCUUACCUCGCUC… 1123 nt 0.3802
NM_001329239.2 NCBI
AGACAGCAGCGACUUUAGGCUGGAUAAUAGUCAAAUUCUUACCUCGCUC… 4012 nt 0.3537
NM_001329240.2 NCBI
AGACAGCAGCGACUUUAGGCUGGAUAAUAGUCAAAUUCUUACCUCGCUC… 3890 nt 0.3483
NM_001329241.2 NCBI
AGACAGCAGCGACUUUAGGCUGGAUAAUAGUCAAAUUCUUACCUCGCUC… 3981 nt 0.3522
NM_006287.6 NCBI
AGACAGCAGCGACUUUAGGCUGGAUAAUAGUCAAAUUCUUACCUCGCUC… 3859 nt 0.3467
Summary

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

Forensic Context

A study in pediatric septic shock patients identified two subclasses based on whole blood RNA expression profiles, where Subclass 1 was characterized by upregulated innate immunity and worse clinical outcomes [Yang et al. DOI:10.1186/s13054-023-04689-y].