Basic Information

Symbol
TFPI2
RNA class
mRNA
Alias
Tissue Factor Pathway Inhibitor 2 TFPI-2 PP5 REF1 Placental Protein 5 Retinal Pigment Epithelium Cell Factor 1
Location (GRCh38)
7:93885396-93890753
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006528.4
Sequence length
2207.0 nt
GC content
0.3706

Transcripts

ID Sequence Length GC content
NM_001271003.2 NCBI
AGAAAGCCGCGCACCUCCUCCCGCCAGGCGCUUUCUCGGACGCCUUGCC… 2174 nt 0.3680
NM_001271004.2 NCBI
AGAAAGCCGCGCACCUCCUCCCGCCAGGCGCUUUCUCGGACGCCUUGCC… 2131 nt 0.3693
NM_006528.4 NCBI
AGAAAGCCGCGCACCUCCUCCCGCCAGGCGCUUUCUCGGACGCCUUGCC… 2207 nt 0.3706
Summary

This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Forensic Context

A study in human and rat skin demonstrated that ultraviolet-B (UVB)-induced inflammation at the peak of hyperalgesia significantly up-regulated the TFPI2 in both species, with a fold change of 15.5 in human skin and 29.2 in rat skin, as part of a large transcriptional response involving numerous cytokines, chemokines, and other mediators [Dawes et al. DOI:10.1371/journal.pone.0093338]. A study in burn-injured rats and human keratinocytes demonstrated that overexpression of the m6A eraser FTO inhibits the TFPI2 mRNA, promoting the proliferation and migration of heat-stimulated keratinocytes and accelerating burn wound healing [Zhang et al. DOI:10.7150/ijbs.114988].