Basic Information

Symbol
TGFA
RNA class
mRNA
Alias
Transforming Growth Factor Alpha Protransforming Growth Factor Alpha Transforming Growth Factor, Alpha TGF-Alpha TFGA
Location (GRCh38)
2:70447284-70554193
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003236.4
Sequence length
4117.0 nt
GC content
0.4455

Transcripts

ID Sequence Length GC content
NM_001099691.3 NCBI
ACUCGGGCACCGCAGGUAGGGCAGGAGGCUGGAGAGCCUGCUGCCCGCC… 4114 nt 0.4453
NM_001308158.2 NCBI
AAUCCGCCGCAGCUGUGUGUCUGCUCAGACACAUGCCUACACCUACCUG… 4281 nt 0.4520
NM_001308159.2 NCBI
AAUCCGCCGCAGCUGUGUGUCUGCUCAGACACAUGCCUACACCUACCUG… 4278 nt 0.4518
NM_003236.4 NCBI
ACUCGGGCACCGCAGGUAGGGCAGGAGGCUGGAGAGCCUGCUGCCCGCC… 4117 nt 0.4455
Summary

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] CIViC Summary for TGFA Gene

Forensic Context

A study in humans demonstrated that TGFA, an EGF family ligand, is rapidly upregulated in migrating keratinocytes during acute wound healing and functions as an autocrine pro-migratory signal [Liu et al. DOI:10.1016/j.stem.2024.11.013].