Basic Information

Symbol
TGFB1I1
RNA class
mRNA
Alias
Transforming Growth Factor Beta 1 Induced Transcript 1 Hic-5 ARA55 TSC-5 Transforming Growth Factor Beta-1-Induced Transcript 1 Protein Androgen Receptor-Associated Protein Of 55 KDa Androgen Receptor Coactivator 55 KDa Protein Hydrogen Peroxide-Inducible Clone 5 Protein Hydrogen Peroxide-Inducible Clone-5 Androgen Receptor Coactivator ARA55 HIC5
Location (GRCh38)
16:31471585-31478727
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001042454.3
Sequence length
1805.0 nt
GC content
0.6349

Transcripts

ID Sequence Length GC content
NM_001042454.3 NCBI
GCCCUGUUCGCCCCGCGCCACCGGCCCGCGCCCCGCCAUGGAGGACCUG… 1805 nt 0.6349
NM_001164719.1 NCBI
GGGGCCGGAUCCCCGGAUGCCCUGCUCUCUGACCUGGAGACUACCACCU… 1782 nt 0.6285
NM_015927.5 NCBI
GGAGAAUAAAAUAAUCAGGAGGCUGGGUUUGUGCUUGGCUCCAAGCAUG… 1801 nt 0.6258
Summary

This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Forensic Context

A study in humans demonstrated that the TGFB1I1 gene expression was down-regulated in menstrual blood-derived stem cells with increasing donor age, identifying it as a key biomarker of cell aging [Chen et al. DOI:PMC4713568]. Another study in severely burned adult humans found that the TGFB1I1 gene was up-regulated in circulating leukocytes from patients with a burn size greater than 40% total body surface area, forming part of a 39-gene signature associated with this injury severity [Sood et al. DOI:10.0000000000000905].