Basic Information

Symbol
TGIF1
RNA class
mRNA
Alias
TGFB Induced Factor Homeobox 1 TGIF 5'-TG-3'-Interacting Factor 1 Homeobox Protein TGIF1 HPE4 Transforming Growth Factor-Beta-Induced Factor TGFB-Induced Factor (TALE Family Homeobox) TALE Homeobox TG-Interacting Factor TGFB-Induced Factor Homeobox 1
Location (GRCh38)
18:3411608-3459978
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003244.4
Sequence length
3175.0 nt
GC content
0.4280

Transcripts

ID Sequence Length GC content
NM_173210.4 NCBI
ACAUUCUUUCAGACCCGGCCCGCUGCGGGGCGUUCCUGGGGGGUAGCCU… 3024 nt 0.4157
NM_173211.2 NCBI
CACAACAUUUCCUUGUAUGUGGAUAGCGUGAAAGAAGCUUGUGAUCCUG… 2924 nt 0.4060
NM_174886.3 NCBI
CAAAAACACAUCUGUUACAAGGGGGAAAGACACCUCCAGGACAACAGUG… 3160 nt 0.4266
Showing 11 to 13 of 13 entries
Summary

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

Forensic Context

A study in mice demonstrated that the TGIF1 transcript, a pro-apoptotic transcription factor, increased in abundance within 0.5 hours postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].