Basic Information

Symbol
TGM2
RNA class
mRNA
Alias
Transglutaminase 2 TGC TG2 C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase Protein-Glutamine Noradrenalinyltransferase TGM2 Protein-Glutamine Gamma-Glutamyltransferase 2 Protein-Glutamine Histaminyltransferase TGM2 Protein-Glutamine Dopaminyltransferase TGM2 Protein-Glutamine Serotonyltransferase TGM2 Protein-Glutamine Deamidase TGM2 Erythrocyte Transglutaminase Tissue Transglutaminase Transglutaminase II Protein G Alpha(H) Transglutaminase C Transglutaminase H Isopeptidase TGM2 Heart G Alpha(H) HhG Alpha(H) EC 2.3.2.13 TGase II TGase C TGase H TGase-2 TTgase TG(C) G(H) HTG2 TTG Transglutaminase 2 (C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase) Transglutaminase-2 EC 3.5.1.44 EC 3.4.-.- EC 2.3.1.-
Location (GRCh38)
20:38127385-38168463
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004613.4
Sequence length
4970.0 nt
GC content
0.5469

Transcripts

ID Sequence Length GC content
NM_001323316.2 NCBI
ACAGUGGAUCCGGAAGCACAGGAGACCAAGAGACCAGAGAUACCAGGAU… 5042 nt 0.5470
NM_001323317.2 NCBI
AGUGCCAGCCGCCAGUGGUCGCACUUGGAGGGUCUCGCCGCCAGUGGAA… 4727 nt 0.5420
NM_001323318.2 NCBI
AGUGCCAGCCGCCAGUGGUCGCACUUGGAGGGUCUCGCCGCCAGUGGAA… 4790 nt 0.5441
NM_004613.4 NCBI
AGUGCCAGCCGCCAGUGGUCGCACUUGGAGGGUCUCGCCGCCAGUGGAA… 4970 nt 0.5469
NM_198951.3 NCBI
AGUGCCAGCCGCCAGUGGUCGCACUUGGAGGGUCUCGCCGCCAGUGGAA… 1857 nt 0.5994
Summary

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice and humans identified the TGM2 as a novel disease gene for sepsis-induced myocardial dysfunction, showing it was up-regulated in LPS-treated mouse models and validated by qRT-PCR and external datasets [Yao et al. DOI:10.1016/j.ygeno.2024.110911]. In a separate study, the TGM2 was found to be up-regulated in human and rat skin following UVB-induced inflammation, with a fold change of 12.5 in human skin and 4.4 in rat skin, indicating its role in inflammatory hyperalgesia [Dawes et al. DOI:10.1371/journal.pone.0093338].