Basic Information

Symbol
THBD
RNA class
mRNA
Alias
Thrombomodulin THRM Fetomodulin BDCA-3 CD141 CD141 Antigen TM THPH12 AHUS6 BDCA3
Location (GRCh38)
20:23045633-23049672
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000361.3
Sequence length
4040.0 nt
GC content
0.5468

Transcripts

ID Sequence Length GC content
NM_000361.3 NCBI
AUGUCAGAGGCUGCCUCGCAGGGGCUGCGCGCAGCGGCAAGAAGUGUCU… 4040 nt 0.5468
Summary

The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that post-mortem thrombomodulin (TM) levels serve as a biomarker for lethal hypothermia, with significantly lower TM mRNA and protein levels in the myocardium and lower TM concentrations in urine in hypothermia deaths compared to controls from cardiovascular disease, trauma, or other causes [Pakanen et al. DOI:10.1007/S00414-014-1138-2].