Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GGCCACGUCCACCGGAGCAUCCUGCACUGCAGGGCCGGUCUCUCGCUCC… | 5527 nt | 0.5066 | |
| GGCCACGUCCACCGGAGCAUCCUGCACUGCAGGGCCGGUCUCUCGCUCC… | 2879 nt | 0.5863 | |
| GGCCACGUCCACCGGAGCAUCCUGCACUGCAGGGCCGGUCUCUCGCUCC… | 6129 nt | 0.5172 | |
| GGCCACGUCCACCGGAGCAUCCUGCACUGCAGGGCCGGUCUCUCGCUCC… | 5701 nt | 0.5120 |
Summary
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008] CIViC Summary for THBS2 Gene
Forensic Context
A study in mice and humans identified the THBS2 as a significant factor influencing hypertrophic scar formation and progression via downstream TGF-β1/P-Smad2/3 pathway activation, where it was identified as one of three key genes specific to hypertrophic scar fibroblasts [Cheng et al. DOI:10.1093/burnst/tkae043]. In a rat model of spinal cord injury, the gene encoding the THBS2 was found to be up-regulated at 1 day post-lesion in both rostral and caudal spinal cord segments [Bighinati et al. DOI:10.3390/ijms22041744].