Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AAUUUGGGGGCUCUUGAGAGAUGAGAGAAACAACGACUGGAGGGAUUAA… | 3069 nt | 0.5178 | |
| AAUUUGGGGGCUCUUGAGAGAUGAGAGAAACAACGACUGGAGGGAUUAA… | 3121 nt | 0.5175 | |
| GGAGCGAUGUAUGCCCAGAGUCUGCUCUUGACAUCCCUGAGAAAGACGC… | 3099 nt | 0.5140 | |
| AGCAGCCAGCUCCCCAGCACCGCACGGCGGGGACGCGAGCGCGCCCCCG… | 3222 nt | 0.5419 |
Summary
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Forensic Context
A study in rats with monocrotaline-induced pulmonary arterial hypertension and right ventricular failure demonstrated that the THBS4 was upregulated 4.4-fold in the right ventricle, where it mediates cell-matrix interactions and is associated with fibrosis and angiogenesis [Potus et al. DOI:10.3390/ijms19092730]. In a separate study in mice subjected to burn injury or formalin-induced inflammatory pain, transcriptomic analysis of the primary somatosensory cortex showed the THBS4 was downregulated as part of overlapping differentially expressed genes in both pain models, associated with extracellular matrix remodeling [Erdei et al. DOI:10.3390/ijms26083538].