Basic Information

Symbol
THRA
RNA class
mRNA
Alias
Thyroid Hormone Receptor Alpha NR1A1 Nuclear Receptor Subfamily 1 Group A Member 1 THRalpha1 THRalpha2 TRalpha1 TRalpha2 C-ERBA-1 THRalpha TRalpha C-ErbA ERBA1 THRA1 THRA2 ERBA AR7 Thyroid Hormone Receptor, Alpha (Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog, Avian) V-ErbA-Related Protein 7 C-ErbA Protooncogene EAR-7.1/EAR-7.2 C-ErbA-Alpha THRA3 EAR-7 EAR7 Thyroid Hormone Receptor, Alpha (Avian Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog) Thyroid Hormone Receptor Alpha 1 Triiodothyronine Receptor ERBA-Related 7 C-ErbA-1 ERB-T-1 CHNG6
Location (GRCh38)
17:40058290-40093867
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_199334.5
Sequence length
5204.0 nt
GC content
0.5915

Transcripts

ID Sequence Length GC content
NM_001190918.2 NCBI
ACUCGCACUCACACCCGGGCGCAGGAGGCGGGCGGCCCGGGCCCCACCG… 2266 nt 0.5984
NM_001190919.2 NCBI
AGCAGAUUGUUGGGGGAAAUGGCUGGUGACAGAGAAUAGAAAGAGCCUA… 2514 nt 0.5784
NM_003250.6 NCBI
ACUCGCACUCACACCCGGGCGCAGGAGGCGGGCGGCCCGGGCCCCACCG… 2383 nt 0.5992
NM_199334.5 NCBI
ACUCGCACUCACACCCGGGCGCAGGAGGCGGGCGGCCCGGGCCCCACCG… 5204 nt 0.5915
Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans (Chinese Han population) developed predictive models to estimate bloodstain deposition time within a 24-hour day-night cycle using rhythmic mRNA expression and machine learning [Cheng et al. DOI:10.1016/J.Fsigen.2023.102910]. A study in humans identified the THRA as one of 11 mRNA markers with statistically significant 24-hour rhythmic expression in blood, with its peak expression occurring between 01:00 h and 03:00 h [Lech et al. DOI:10.1016/J.Fsigen.2015.12.008].