Basic Information

Symbol
THSD7A
RNA class
mRNA
Alias
Thrombospondin Type 1 Domain Containing 7A KIAA0960 Thrombospondin Type-1 Domain-Containing Protein 7A Thrombospondin, Type I, Domain Containing 7A
Location (GRCh38)
7:11370365-11832198
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015204.3
Sequence length
10655.0 nt
GC content
0.4249

Transcripts

ID Sequence Length GC content
NM_015204.3 NCBI
AUUCUGCGAGGAAUGGCAGCGGCAGCAGCAUCCCCGCCAGAGGCGGCGG… 10655 nt 0.4249
Summary

The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

Forensic Context

A study in human heart tissue from sudden unexplained death (SUD) cases demonstrated that the THSD7A was significantly upregulated in the "primary normal" SUD subgroup compared to heart-healthy controls, where it is involved in angiogenesis [Neubauer et al. DOI:10.1007/S00414-025-03414-4]. This differential expression was identified through whole transcriptome sequencing and DESeq2 analysis, contributing to the unique gene expression pattern observed in that specific pathological subgroup.