Basic Information

Symbol
THY1
RNA class
mRNA
Alias
Thy-1 Cell Surface Antigen CD90 Thy-1 Membrane Glycoprotein Thy-1 Antigen CDw90 Thy-1 T-Cell Antigen CD90 Antigen
Location (GRCh38)
11:119415476-119424985
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006288.5
Sequence length
4502.0 nt
GC content
0.5613

Transcripts

ID Sequence Length GC content
NM_001311160.2 NCBI
UUUGGGAAAGGAGAGGAUUGGAAUACGGAAAUGGAUUAAGGAUGAGGCC… 5394 nt 0.5608
NM_001311162.2 NCBI
CAGAAUCAGAAAGCUGUUAAGCAGGAAGGAGUGCGCUGCCAUGAAGAGG… 4530 nt 0.5585
NM_001372050.1 NCBI
AGCAACCGGAGGCGGCGGCGCGUCUGGAGGAGGCUGCAGCAGCGGAAGA… 4451 nt 0.5605
NM_006288.5 NCBI
AGCAACCGGAGGCGGCGGCGCGUCUGGAGGAGGCUGCAGCAGCGGAAGA… 4502 nt 0.5613
Summary

This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Forensic Context

A study in rats demonstrated that the THY1 protein and mRNA levels in adipose-derived stem cells (ASCs) were not significantly different between burned and non-burned animals, indicating its stable expression as a positive identification marker for ASCs unaffected by burn injury [Prasai et al. DOI:10.007/s12015-017-9721-9]. Research in human menstrual blood-derived stem cells (MenSCs) found the THY1 was highly expressed across all donor age groups and at different passage numbers, confirming its role as a stable stromal cell marker whose immunophenotype did not change significantly with aging or in vitro culture [Chen et al. DOI:PMC4713568]. A study in mice demonstrated that the THY1 (Thy-1/CD90) was used as a canonical marker for fibroblast identification in radiation-induced skin injury, where its expression was notably absent in an identified "apoptotic fibroblast" cluster [Yu et al. DOI:10.1186/s40164-025-00596-w]. In human corpus cavernosum research, the THY1 was identified as a gene/protein marker highly expressed in the SMC3 (pericytes) subcluster and part of fibroblasts, with THY1+ cells detected around small vessels, providing spatial localization data [Zhao et al. DOI:10.1038/s41467-022-31950-9].