Basic Information

Symbol
TIA1
RNA class
mRNA
Alias
TIA1 Cytotoxic Granule Associated RNA Binding Protein TIA-1 T-Cell-Restricted Intracellular Antigen-1 Cytotoxic Granule Associated RNA Binding Protein TIA1 Nucleolysin TIA-1 Isoform P40 TIA1 Cytotoxic Granule-Associated RNA-Binding Protein P40-TIA-1 (Containing P15-TIA-1) RNA-Binding Protein TIA-1 P40-TIA-1 ALS26 WDM
Location (GRCh38)
2:70209444-70248761
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022173.4
Sequence length
4634.0 nt
GC content
0.3651

Transcripts

ID Sequence Length GC content
NM_001351508.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4631 nt 0.3649
NM_001351509.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4607 nt 0.3642
NM_001351510.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4598 nt 0.3639
NM_001351511.1 NCBI
CUGCGCAGUCUGAGGCGUCCCUCGCGUCGGGUGGAAGAGCGGCUGCGCA… 4541 nt 0.3616
NM_001351512.1 NCBI
CUGCGCAGUCUGAGGCGUCCCUCGCGUCGGGUGGAAGAGCGGCUGCGCA… 4514 nt 0.3607
NM_001351513.1 NCBI
CUGCGCAGUCUGAGGCGUCCCUCGCGUCGGGUGGAAGAGCGGCUGCGCA… 4508 nt 0.3605
NM_001351514.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4504 nt 0.3635
NM_001351515.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4720 nt 0.3642
NM_001351516.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 1053 nt 0.4425
NM_001351517.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4849 nt 0.3658
Showing 1 to 10 of 20 entries
Summary

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]

Forensic Context

A study in human fetal cortical tissue demonstrated that prenatal alcohol exposure induces widespread alternative splicing changes, including the identification of previously unknown isoforms of the RNA-binding protein TIA1, which is involved in endoplasmic reticulum stress response and cell death control [Kawasawa et al. DOI:10.1016/J.Alcohol.2017.05.001].