Basic Information

Symbol
TIA1
RNA class
mRNA
Alias
TIA1 Cytotoxic Granule Associated RNA Binding Protein TIA-1 T-Cell-Restricted Intracellular Antigen-1 Cytotoxic Granule Associated RNA Binding Protein TIA1 Nucleolysin TIA-1 Isoform P40 TIA1 Cytotoxic Granule-Associated RNA-Binding Protein P40-TIA-1 (Containing P15-TIA-1) RNA-Binding Protein TIA-1 P40-TIA-1 ALS26 WDM
Location (GRCh38)
2:70209444-70248761
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022173.4
Sequence length
4634.0 nt
GC content
0.3651

Transcripts

ID Sequence Length GC content
NM_001351518.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 995 nt 0.4402
NM_001351519.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 802 nt 0.4539
NM_001351520.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 927 nt 0.4434
NM_001351521.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 769 nt 0.4512
NM_001351522.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 868 nt 0.4528
NM_001351523.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 672 nt 0.4598
NM_001351524.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4629 nt 0.3651
NM_001351525.2 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4667 nt 0.3651
NM_022037.4 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4601 nt 0.3641
NM_022173.4 NCBI
GCCGCCAUCUUGUAUUGGGGUUUCAUUGUUCCCGCUGGGCCGGGCGGUU… 4634 nt 0.3651
Showing 11 to 20 of 20 entries
Summary

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]

Forensic Context

A study in human fetal cortical tissue demonstrated that prenatal alcohol exposure induces widespread alternative splicing changes, including the identification of previously unknown isoforms of the RNA-binding protein TIA1, which is involved in endoplasmic reticulum stress response and cell death control [Kawasawa et al. DOI:10.1016/J.Alcohol.2017.05.001].