Basic Information

Symbol
TICAM1
RNA class
mRNA
Alias
TIR Domain Containing Adaptor Molecule 1 TICAM-1 PRVTIRB TRIF Proline-Rich, Vinculin And TIR Domain-Containing Protein B Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta TIR Domain-Containing Adapter Protein Inducing IFN-Beta Putative NF-Kappa-B-Activating Protein 502H TIR Domain-Containing Adapter Molecule 1 Toll Like Receptor Adaptor Molecule 1 MGC35334 MyD88-3 TIR Domain-Containing Adaptor-Inducing Interferon-Beta TIR Domain Containing Adaptor Inducing Interferon-Beta Toll-Like Receptor Adaptor Molecule 1 IIAE6
Location (GRCh38)
19:4815932-4831712
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_182919.4
Sequence length
2684.0 nt
GC content
0.6300

Transcripts

ID Sequence Length GC content
NM_001385678.1 NCBI
AGCGCCCUCAGCGCGCUACGGUCCGCGGGCAACUCCGCAGAAGCCCCAG… 2541 nt 0.6297
NM_001385679.1 NCBI
AGCGCCCUCAGCGCGCUACGGUCCGCGGGCAACUCCGCAGAAGCCCCAG… 2499 nt 0.6311
NM_001385680.1 NCBI
AGCGCCCUCAGCGCGCUACGGUCCGCGGGCAACUCCGCAGAAGCCCCAG… 2107 nt 0.6251
NM_182919.4 NCBI
AGCGCCCUCAGCGCGCUACGGUCCGCGGGCAACUCCGCAGAAGCCCCAG… 2684 nt 0.6300
Summary

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]

Forensic Context

A study in humans demonstrated that the TICAM1 was significantly expressed in non-classical monocytes from patients with plaque rupture [Jun Qian et al. DOI:10.3389/fimmu.2022.908815]. In human and mouse models, the TICAM1 was identified as the essential signaling adaptor protein TRIF, which is necessary for the inflammatory cytokine production induced by UVB-damaged self-RNA in keratinocytes and peripheral blood mononuclear cells and for the response to UVB exposure in vivo [Bernard et al. DOI:10.1038/nm.2861]. A study in humans demonstrated that severe trauma induces a unique bone marrow transcriptomic signature characterized by upregulation of genes involved in innate immunity and erythropoiesis inhibition, including components of the TLR4 signaling pathway [Kelly et al. DOI:10.1097/SHK.0000000000001826].