Basic Information

Symbol
TIMELESS
RNA class
mRNA
Alias
Timeless Circadian Regulator HTIM TIM1 TIM Timeless Circadian Clock 1 Protein Timeless Homolog Timeless (Drosophila) Homolog Timeless Homolog (Drosophila) Tof1 Homolog (S. Cerevisiae) Timeless Homolog Tof1 Homolog TIMELESS1 FASPS4
Location (GRCh38)
12:56416363-56449445
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003920.5
Sequence length
5158.0 nt
GC content
0.5188

Transcripts

ID Sequence Length GC content
NM_001330295.2 NCBI
GCCUCGCUCUUCGCGCAGGCGGGGACCGGUCCAGCUGAGCCUGGUGGCG… 5155 nt 0.5189
NM_003920.5 NCBI
GCCUCGCUCUUCGCGCAGGCGGGGACCGGUCCAGCUGAGCCUGGUGGCG… 5158 nt 0.5188
Summary

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]

Forensic Context

No relevant information is available at the moment.