Basic Information

Symbol
TIMP3
RNA class
mRNA
Alias
TIMP Metallopeptidase Inhibitor 3 Tissue Inhibitor Of Metalloproteinases 3 Metalloproteinase Inhibitor 3 Protein MIG-5 TIMP-3 SFD Tissue Inhibitor Of Metalloproteinase 3 (Sorsby Fundus Dystrophy, Pseudoinflammatory) MIG-5 Protein HSMRK222 K222TA2 K222
Location (GRCh38)
22:32801576-32863042
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000362.5
Sequence length
4597.0 nt
GC content
0.4866

Transcripts

ID Sequence Length GC content
NM_000362.5 NCBI
AGAGCGGGCAGCAGGCAGGCGGCGGGCGCUCAGACGGCUUCUCCUCCUC… 4597 nt 0.4866
Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human ex vivo skin explants demonstrated that TIMP3 (TIMP Metallopeptidase Inhibitor 3) mRNA was significantly upregulated in burned tissue at 24 hours post-burn, identifying it as an early burn response gene [Foessl et al. DOI:10.3390/ijms22179209]. A study in rats demonstrated that the TIMP3 mRNA was upregulated at 24 hours after a 10–11 psi blast exposure and at all measured time points following a 14–15 psi blast exposure, correlating with vascular injury and wound healing processes in a model of mild traumatic brain injury [Balaban et al. DOI:10.1016/j.jneumeth.2016.02.001].