Basic Information

Symbol
BEX2
RNA class
mRNA
Alias
Brain Expressed X-Linked 2 DJ79P11.1 Brain-Expressed X-Linked Protein 2 Protein BEX2 HBex2 BEX1
Location (GRCh38)
X:103309345-103311298
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032621.4
Sequence length
843.0 nt
GC content
0.4887

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-266.60 kcal/mol
Thermodynamic ensemble
Free energy: -285.01 kcal/mol
Frequency: 0.0000
Diversity: 247.90
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((((.......(((.(((((((.((((((..((((((((((.(((.((.((.(((((((..((((.(((((....)))))..)))).))))))).)).((.......))..)).)))))))))).........(((((...(.(((((((..(...((((.((........)).)))).)..).)))))).)...))))).(((.(.....).)))...)))..))).)))..........(((((((......((.....)).....))))))).............((((...(((((((((((((((.(((...)))))..))))....)))))))))...((((((((((((.((((.(((....)))))))...))))))..((((((..........)))))).......))))))))))(((((.(((((((..(((((((.(((((.......((((((((((((((..((((((((((..(((((((......((((((....((((............))))(((((((....)))).)))))))))......)))))).)....))))))))))...)))).))))))...((((((((((.......)))))))))).....))))......(((((.......)))))))))).)))).(((((....))))).)))....))))))).)))))......(((((((.....))).)))).))))))))))....)))))((((((((((.(((.........))).))).)))))))..((((..(((...(((((............)))))..)))..))))
Thermodynamic Ensemble Prediction
{{(,{{{,{|,|,...(((,((((({{.,{(,(((.(((.(((((((((((((.((((((((((..((((.(((((....)))))..)))).))))))){||{(({,,,.,.,,..}|.,,..}},.,).},)}},)))})}}..,,{,{(((,,..)))}|||))))))))))}..)))))))),.)}),}}.((({..((((((.{{{.,{{{{.{(((.....))|,|.,(({({,,,..,{{(((((((......,,.....)}.....))))))}....,||....,{{.||,.,{{(((((((((((((.(((...)))}),.))))}...,})))))}}...||{{,(((((((.(({{((((....))))))).,.}))))),,((((({,||......,)))))).,....,||,,,|{{{{(,,||,||,||||},{{{{(((.{((((.......{{,,((((((((((,.((((((((((..(((((((....{.((((((....((((.,........,.))))(((((((....)))).))))))))).}.,..)))))).)....)))))))))).,.)))}.))))))...((((((((((.......)))))))))),,...)))),...,.{{(((....,,,)))),))))).)))).,{{||,,,,))))).}))}}}.))),)))})))))}.....(((((((.....))).)))).}}}))})))},,..|||||{{(((,{{,{{{|,|{.,..,,,))}.}))},})),}),,|||{,.{{,...{{{||,...........))}}}..,,,..))).

Transcripts

ID Sequence Length GC content
NM_001168399.2 NCBI
GAGUCUUACCUCGUUGUGGCGUCAGAACCGCCGUCGCUCGCUCCCUUCU… 1120 nt 0.5437
NM_001168400.2 NCBI
GAGUCUUACCUCGUUGUGGCGUCAGAACCGCCGUCGCUCGCUCCCUUCU… 1117 nt 0.5434
NM_001168401.2 NCBI
GAGUCUUACCUCGUUGUGGCGUCAGAACCGCCGUCGCUCGCUCCCUUCU… 807 nt 0.4808
NM_032621.4 NCBI
GAGUCUUACCUCGUUGUGGCGUCAGAACCGCCGUCGCUCGCUCCCUUCU… 843 nt 0.4887
Summary

This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Forensic Context

A study in mice demonstrated that the BEX2 was identified as a network hub node with differing relative connectivity between lines among ventral midbrain differentially expressed genes overexpressed in the methamphetamine high drinking (MAHDR) line [Hitzemann et al. DOI:10.3390/brainsci9070155].