Basic Information

Symbol
TINCR
RNA class
mRNA
Alias
TINCR Ubiquitin Domain Containing NCRNA00036 LINC00036 Onco-LncRNA-16 PLAC2 TUBL Tissue Differentiation-Inducing Non-Protein Coding RNA Long Intergenic Non-Protein Coding RNA 36 Placenta-Specific 2 (Non-Protein Coding) Terminal Differentiation-Induced NcRNA TINCR-Encoded Ubiquitin-Like Protein FLJ90734 Terminal Differentiation-Induced Cornification Regulator Ubiquitin Domain-Containing Protein TINCR Placenta-Specific Protein 2 Non-Protein Coding RNA 36 Placenta-Specific 2
Location (GRCh38)
19:5558167-5578349
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001396408.1
Sequence length
3652.0 nt
GC content
0.5789

Transcripts

ID Sequence Length GC content
NM_001396408.1 NCBI
AGAGCUGGAGCCGGAGCCGGGCGGGCGCCAUGGAGGGGCUGCGGCGGGG… 3652 nt 0.5789
NM_001396409.1 NCBI
AGAGCUGGAGCCGGAGCCGGGCGGGCGCCAUGGAGGGGCUGCGGCGGGG… 604 nt 0.6192
Summary

This gene produces a spliced long non-coding RNA that binds RNAs. This transcript interacts with staufen-1 protein to regulate the stability of mRNAs for genes involved in the differentiation of epidermal tissue. Variation in this gene may be associated with cancer progression. [provided by RefSeq, Aug 2017]

Forensic Context

A study in human epidermal differentiation demonstrated that the TINCR is a cytoplasmic long noncoding RNA induced upon terminal differentiation, where it interacts with STAU1 to stabilize mRNAs encoding proteins critical for terminally differentiated keratinocytes, and it is downregulated in human squamous cell carcinoma [Flynn and Chang DOI:10.1016/j.stem.2014.05.014].