Basic Information

Symbol
TIPARP
RNA class
mRNA
Alias
TCDD Inducible Poly(ADP-Ribose) Polymerase ARTD14 PARP7 PARP-7 PART14 ADP-Ribosyltransferase Diphtheria Toxin-Like 14 Protein Mono-ADP-Ribosyltransferase TIPARP Poly [ADP-Ribose] Polymerase 7 DKFZp686N0351 DKFZP434J214 PARP-1 DDF1 RM1 TCDD-Inducible Poly [ADP-Ribose] Polymerase TCDD-Inducible Poly(ADP-Ribose) Polymerase EC 2.4.2.-
Location (GRCh38)
3:156673235-156706770
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015508.5
Sequence length
3861.0 nt
GC content
0.4084

Transcripts

ID Sequence Length GC content
NM_001184717.1 NCBI
AUUGAUUUUGAGACUGCCCUUUGUACCGAAUUCACUCGGGUCCCGUCAG… 4132 nt 0.4177
NM_001184718.2 NCBI
CACCAUUCCUUUCUCACCUGGCACAAUCUCAGAUUUUUAGACUCUGAGG… 3685 nt 0.3927
NM_015508.5 NCBI
AGAGAUCGAGGUGACAGGCGAGCUGGCUGGACUCGGAGCGCGGUCGAGG… 3861 nt 0.4084
Summary

This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Forensic Context

A study in mice demonstrated that the TIPARP gene was upregulated in common in spleen leukocytes across all three injury models of trauma/hemorrhage, burn, and LPS infusion, indicating its role as part of a common early transcriptional response to systemic inflammation [Brownstein et al. DOI:10.1152/physiolgenomics.00213.2005]. Furthermore, a review consolidating research across multiple species noted that the TIPARP is a target gene derepressed by specific circRNAs, such as circTLK1 and circHECTD1, following ischemic stroke, where its upregulation is associated with worsening injury and astrocyte activation [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].