Basic Information

Symbol
TIRAP
RNA class
mRNA
Alias
TIR Domain Containing Adaptor Protein Wyatt Mal Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein MyD88 Adapter-Like Protein Adaptor Protein Wyatt MyD88-2 Toll-Interleukin 1 Receptor (TIR) Domain-Containing Adaptor Protein Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein TIR Domain-Containing Adapter Protein Toll-Like Receptor Adaptor Protein Adapter Protein Wyatt MyD88 Adapter-Like BACTS1 MAL
Location (GRCh38)
11:126282497-126298845
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001318777.2
Sequence length
2189.0 nt
GC content
0.5391

Transcripts

ID Sequence Length GC content
NM_001039661.2 NCBI
CUCUUCCCCGCGGAGCCCGCGCAGUCCGCGCAGCCCUCAUCGCAACUGG… 2342 nt 0.5384
NM_001318776.2 NCBI
CUCUUCCCCGCGGAGCCCGCGCAGUCCGCGCAGCCCUCAUCGCAACUGG… 1044 nt 0.6006
NM_001318777.2 NCBI
CUCUUCCCCGCGGAGCCCGCGCAGUCCGCGCAGCCCUCAUCGCAACUGG… 2189 nt 0.5391
NM_148910.3 NCBI
CUCUUCCCCGCGGAGCCCGCGCAGUCCGCGCAGCCCUCAUCGCAACUGG… 1213 nt 0.5894
Summary

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.