Basic Information

Symbol
TJP1
RNA class
mRNA
Alias
Tight Junction Protein 1 Tight Junction Protein ZO-1 ZO-1 Zona Occludens 1 DKFZp686M05161 MGC133289 Zonula Occludens 1 Protein Zonula Occludens Protein 1 Zona Occludens Protein 1 ZO1
Location (GRCh38)
15:29699367-29968915
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001330239.4
Sequence length
7190.0 nt
GC content
0.4498

Transcripts

ID Sequence Length GC content
NM_001301025.3 NCBI
GCCGCCGGGCCACGGCCUGCAGGGGUGGAAGGGGCGGCGGCGGCGGGAG… 8024 nt 0.4452
NM_001301026.2 NCBI
ACUCCACUCAGCCUGUGAGGCGUAGUAGGUCGGGUUUUCUUUCAUGCUG… 7480 nt 0.4273
NM_001330239.4 NCBI
GUGGCCGCUGAGUUGCCGGCGCCGGCUGAGCCAGCGGACGCCGCGUUCC… 7190 nt 0.4498
NM_001355012.2 NCBI
GCCGCCGGGCCACGGCCUGCAGGGGUGGAAGGGGCGGCGGCGGCGGGAG… 7964 nt 0.4445
NM_001355013.1 NCBI
GAGGAAAGGCUUUGUUUCCGUAUUACACAGAAUGUCACUUUGUUCCUGA… 7638 nt 0.4262
NM_001355014.2 NCBI
GUGGCCGCUGAGUUGCCGGCGCCGGCUGAGCCAGCGGACGCCGCGUUCC… 7936 nt 0.4471
NM_001355015.2 NCBI
GUGGCCGCUGAGUUGCCGGCGCCGGCUGAGCCAGCGGACGCCGCGUUCC… 7735 nt 0.4474
NM_003257.5 NCBI
GUGGCCGCUGAGUUGCCGGCGCCGGCUGAGCCAGCGGACGCCGCGUUCC… 7915 nt 0.4466
NM_175610.4 NCBI
GUGGCCGCUGAGUUGCCGGCGCCGGCUGAGCCAGCGGACGCCGCGUUCC… 7675 nt 0.4468
Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Forensic Context

A study in human keratinocytes and mouse skin demonstrated that X-ray irradiation (5 Gy) significantly downregulated the TJP1 gene expression to 0.37-fold at 3 hours post-exposure, identifying it among 59 downregulated genes associated with skin injury [Koike et al. DOI:10.1269/jrr.46.173]. A study in pigs demonstrated that the TJP1 was down-regulated in subcutaneous fat after high-force impact in experimental bruises, and its expression signature, as part of a 13-gene panel, enabled age determination with a precision of approximately ±2 hours [Barington et al. DOI:10.007/s12024-017-9869-2]. In mice, hyperoxia exposure leading to diffuse alveolar damage resulted in a significant down-regulation of the TJP1 mRNA in lung tissue, suggesting associated alveolar dysfunction [Shimada et al. DOI:10.1007/S00414-008-0226-6].