Basic Information

Symbol
TLE2
RNA class
mRNA
Alias
TLE Family Member 2, Transcriptional Corepressor ESG2 GRG2 ESG Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila) Enhancer Of Split Groucho-Like Protein 2 Transducin Like Enhancer Of Split 2 Transducin-Like Enhancer Protein 2 FLJ41188 Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1) Enhancer Of Split Groucho 2
Location (GRCh38)
19:2997639-3047635
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003260.5
Sequence length
2812.0 nt
GC content
0.6469

Transcripts

ID Sequence Length GC content
NM_001144761.2 NCBI
GAAAAUUGUACUGAGAAUUAGAACUUCUGCAAGGGCUCAAGAGUGUCAG… 2485 nt 0.6125
NM_001144762.2 NCBI
ACUUGCUCAGAAAAGCCAUUUCCGACUCCAGACUGGUCCCCGCUCCCCG… 2284 nt 0.6156
NM_001300846.2 NCBI
GCCGAGCCCCGCCGGAGGGAGGCGGCUCCGCGCGGGGCCCGCCGCCCGC… 2815 nt 0.6469
NM_003260.5 NCBI
GCCGAGCCCCGCCGGAGGGAGGCGGCUCCGCGCGGGGCCCGCCGCCCGC… 2812 nt 0.6469
Summary

Enables transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that repeated cocaine exposure increased transcription factor E2F3a levels in the nucleus accumbens, and viral-mediated overexpression of E2F3a enhanced cocaine-induced locomotor sensitization and conditioned place preference while recapitulating cocaine's transcriptional and alternative splicing profiles [Cates et al. DOI:10.1016/j.biopsych.2017.11.027].