Basic Information

Symbol
TLE3
RNA class
mRNA
Alias
TLE Family Member 3, Transcriptional Corepressor ESG3 KIAA1547 HsT18976 GRG3 ESG Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila) Enhancer Of Split Groucho-Like Protein 3 Transducin Like Enhancer Of Split 3 Transducin-Like Enhancer Protein 3 Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1) Enhancer Of Split Groucho 3
Location (GRCh38)
15:70047790-70098176
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001105192.3
Sequence length
5736.0 nt
GC content
0.5898

Transcripts

ID Sequence Length GC content
NM_001105192.3 NCBI
AGUCCCUAUUUGGAACUGCUCUCGCGGCAGUUCAGACCUCGUGCUCGUC… 5736 nt 0.5898
NM_001282979.2 NCBI
AGUCCCUAUUUGGAACUGCUCUCGCGGCAGUUCAGACCUCGUGCUCGUC… 5721 nt 0.5899
NM_001282980.2 NCBI
AGUCCCUAUUUGGAACUGCUCUCGCGGCAGUUCAGACCUCGUGCUCGUC… 5730 nt 0.5895
NM_001282981.2 NCBI
AUUUAAGCAUCUAUCAUGGCAGGGUAAACGAGGCAGUUUAUCUGGCACC… 4669 nt 0.5545
NM_001282982.2 NCBI
ACAUAAUAUAACGUUCUGUUGAGAUGAGAGGAACGCUCGCCCUUGUCAG… 4480 nt 0.5565
NM_005078.4 NCBI
AGUCCCUAUUUGGAACUGCUCUCGCGGCAGUUCAGACCUCGUGCUCGUC… 5745 nt 0.5894
NM_020908.3 NCBI
AGUCCCUAUUUGGAACUGCUCUCGCGGCAGUUCAGACCUCGUGCUCGUC… 5709 nt 0.5898
Summary

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Forensic Context

A study in rats demonstrated that the TLE3 (Tle3) was identified as a potential regulator of methamphetamine reward and addiction through transcriptome profiling of whisker follicles, where its expression was down-down regulated (0.70 at MASA, 0.35 at WD) and it was prioritized via topological network analysis with a betweenness centrality score of 0.0134 [Song et al. DOI:10.1038/s41598-018-29772-1].