Basic Information

Symbol
TLK2
RNA class
mRNA
Alias
Tousled Like Kinase 2 PKU-ALPHA Serine/Threonine-Protein Kinase Tousled-Like 2 Tousled-Like Kinase 2 EC 2.7.11.1 MGC44450 HsHPK PKU-Alpha EC 2.7.11 MRD57
Location (GRCh38)
17:62458658-62615481
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006852.6
Sequence length
5640.0 nt
GC content
0.4640

Transcripts

ID Sequence Length GC content
NM_001284333.3 NCBI
CUCUCGUGGAGCCCGGCGCCGGCGGCGGCUGCCCGGGCGGGGGGUUGCG… 5410 nt 0.4468
NM_001284363.1 NCBI
AAGGAAUUUUCUUUUUGCAGCAGAAAUGAUGGAAGAAUUGCAUAGCCUG… 5113 nt 0.4283
NM_001330418.3 NCBI
CUCUCGUGGAGCCCGGCGCCGGCGGCGGCUGCCCGGGCGGGGGGUUGCG… 5397 nt 0.4399
NM_001375269.1 NCBI
GAGGGCUGCGGGUCGCUGAGGGGCCGGGCAGAAGAUGGGGGAGGCCCAG… 5245 nt 0.4416
NM_001375270.1 NCBI
CACUACUAAUCCGGACCGAACCGAUCCGGAUUAAGGGGCCGGAGGCGGG… 5638 nt 0.4640
NM_001375271.1 NCBI
CUUGCCCGCUAGAUAGUUCUCAUUCCUCAGGAGAUACUCUGUGAGGGGC… 5442 nt 0.4423
NM_001375272.1 NCBI
CACUACUAAUCCGGACCGAACCGAUCCGGAUUAAGGGGCCGGAGGCGGG… 5542 nt 0.4621
NM_001375273.1 NCBI
CACUACUAAUCCGGACCGAACCGAUCCGGAUUAAGGGGCCGGAGGCGGG… 5688 nt 0.4580
NM_001411074.1 NCBI
ACUACUAAUCCGGACCGAACCGAUCCGGAUUAAGGGGCCGGAGGCGGGU… 5352 nt 0.4630
NM_006852.6 NCBI
ACUACUAAUCCGGACCGAACCGAUCCGGAUUAAGGGGCCGGAGGCGGGU… 5640 nt 0.4640
Summary

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] CIViC Summary for TLK2 Gene

Forensic Context

A study in cynomolgus monkeys demonstrated that chronic exposure to methamphetamine or heroin downregulated the TLK2 gene, which is related to the cell cycle, compared to control and cocaine-treated groups, as confirmed by RNA-Seq and RT-qPCR analyses [Choi et al. DOI:10.30773/pi.2022.0004].