Basic Information

Symbol
TLL2
RNA class
mRNA
Alias
Tolloid Like 2 Tolloid-Like Protein 2 EC 3.4.24.19 EC 3.4.24.- EC 3.4.24 KIAA0932
Location (GRCh38)
10:96364608-96513941
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012465.4
Sequence length
6769.0 nt
GC content
0.4853

Transcripts

ID Sequence Length GC content
NM_012465.4 NCBI
ACACUCGCAGCCGCCGCAGCCUCGGCCGCCGGGCAAGUAGCUCCGAGCG… 6769 nt 0.4853
Summary

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans analyzing heart tissue samples from patients with various structural heart diseases identified a 62-gene expression signature, including the TLL2, which was significantly up-regulated in diseased samples (mean fold change 1.7020, adjusted p-value 1.9225 × 10^-32) [Fajarda et al. DOI:10.1186/s13040-020-00217-8].