Basic Information

Symbol
TLN2
RNA class
mRNA
Alias
Talin 2 KIAA0320 ILWEQ Talin-2
Location (GRCh38)
15:62390512-62844631
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015059.3
Sequence length
12023.0 nt
GC content
0.5319

Transcripts

ID Sequence Length GC content
NM_001394547.1 NCBI
GUUCCGCGCCCGGAGCCAGCGGCGGCGGCAGCGGCUGAGGCGGCUGCGG… 11898 nt 0.5320
NM_015059.3 NCBI
GUUCCGCGCCCGGAGCCAGCGGCGGCGGCAGCGGCUGAGGCGGCUGCGG… 12023 nt 0.5319
Summary

This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly downregulated the TLN2 in cortical microglia, as part of broader dysregulation in the Rap1 signaling pathway [Oladapo et al. DOI:10.3390/Ijms26020649].