Basic Information

Symbol
TLR2
RNA class
mRNA
Alias
Toll Like Receptor 2 TIL4 Toll-Like Receptor 2 CD282 Toll/Interleukin-1 Receptor-Like Protein 4 CD282 Antigen
Location (GRCh38)
4:153684050-153708537
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001318789.2
Sequence length
3596.0 nt
GC content
0.4049

Transcripts

ID Sequence Length GC content
NM_001318787.2 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3806 nt 0.4073
NM_001318789.2 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3596 nt 0.4049
NM_001318790.2 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3573 nt 0.4036
NM_001318791.2 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3562 nt 0.4051
NM_001318793.2 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3558 nt 0.4042
NM_001318795.2 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3537 nt 0.4032
NM_001318796.2 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3522 nt 0.4037
NM_003264.5 NCBI
AGGCCGGCUCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCUGCUCGGCG… 3581 nt 0.4055
Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Forensic Context

A study in rats demonstrated that the TLR2 exhibits a time-dependent increase in mRNA expression in skin wound tissue, peaking at 1 day post-injury and showing a strong positive correlation with HMGB1 and TLR4 expression [Abd-Elhakim et al. DOI:10.1007/S00414-022-02788-Z]. A study in mice demonstrated that the TLR2 (Tlr2) was identified as a key hub gene significantly associated with acute myocardial infarction (AMI), with its expression downregulated in infarcted left ventricular tissues across multiple time points [Wu et al. DOI:10.1016/j.ygeno.2023.110701].