Basic Information

Symbol
TLR6
RNA class
mRNA
Alias
Toll Like Receptor 6 Toll-Like Receptor 6 CD286 CD286 Antigen
Location (GRCh38)
4:38822897-38856901
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006068.5
Sequence length
6698.0 nt
GC content
0.4279

Transcripts

ID Sequence Length GC content
NM_001394553.1 NCBI
CCUUUCUCUUCCUCCUGAAAGCAGAAGUGAUUCUUACGGAGAUGUCCAA… 6709 nt 0.4290
NM_006068.5 NCBI
AAUUGUAUUUCCGUUCAUUUACAAGUUAUUUUCUCUUCUUCUGAAAAAG… 6698 nt 0.4279
Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

Forensic Context

A study in humans identified the TLR6 as a differentially expressed gene in the dorsolateral prefrontal cortex associated with alcohol use disorder (AUD) and found it was significantly associated with problematic alcohol use in a genome-wide association study lookup [Willis et al. DOI:10.1038/S41380-024-02777-1].