Basic Information

Symbol
TLR8
RNA class
mRNA
Alias
Toll Like Receptor 8 Toll-Like Receptor 8 CD288 HTLR8 CD288 Antigen IMD98 TLR-8
Location (GRCh38)
X:12906620-12923169
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_138636.5
Sequence length
4216.0 nt
GC content
0.3961

Transcripts

ID Sequence Length GC content
NM_016610.4 NCBI
AGUUUCUCUUCUCGGCCACCUCCUGCAUAGAGGGUACCAUUCUGCGCUG… 4353 nt 0.3983
NM_138636.5 NCBI
AGUUUCUCUUCUCGGCCACCUCCUGCAUAGAGGGUACCAUUCUGCGCUG… 4216 nt 0.3961
Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human skin demonstrated that TLR8, an inflammatory/immune response gene, was significantly up-regulated in thermally injured tissue compared to normal skin during the early wound repair process [Greco et al. DOI:10.1016/j.burns.2009.06.211].