Basic Information

Symbol
TM7SF2
RNA class
mRNA
Alias
Transmembrane 7 Superfamily Member 2 ANG1 DHCR14A NET47 3-Beta-Hydroxysterol Delta (14)-Reductase Delta(14)-Sterol Reductase TM7SF2 Putative Sterol Reductase SR-1 Another New Gene 1 Protein C-14 Sterol Reductase Sterol C14-Reductase Delta-14-SR EC 1.3.1.70 C14SR Delta(14)-Sterol Reductase EC 1.3.1
Location (GRCh38)
11:65111845-65116384
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003273.6
Sequence length
1578.0 nt
GC content
0.6236

Transcripts

ID Sequence Length GC content
NM_001277233.2 NCBI
GUCUGCGUUCCGUGUCCAGGCAGGUGCAGGCGCCGCGGGGCCGGAUCCU… 1497 nt 0.6306
NM_003273.6 NCBI
GUCUGCGUUCCGUGUCCAGGCAGGUGCAGGCGCCGCGGGGCCGGAUCCU… 1578 nt 0.6236
Summary

Enables Delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in mice demonstrated that the TM7SF2 gene expression was significantly up-regulated in liver tissue following combined alcohol and high-fat diet-induced injury, and this up-regulation was suppressed after scoparone intervention [Wei et al. DOI:10.1016/J.Biopha.2022.113770].