Basic Information

Symbol
BGLAP
RNA class
mRNA
Alias
Bone Gamma-Carboxyglutamate Protein Gamma-Carboxyglutamic Acid-Containing Protein Osteocalcin OCN BGP Bone Gla Protein Bone Gamma-Carboxyglutamate (Gla) Protein (Osteocalcin) Bone Gamma-Carboxyglutamate (Gla) Protein OC
Location (GRCh38)
1:156242184-156243317
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_199173.6
Sequence length
506.0 nt
GC content
0.6265

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-197.70 kcal/mol
Thermodynamic ensemble
Free energy: -205.03 kcal/mol
Frequency: 0.0000
Diversity: 142.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((.(..(((....((((((.(((..((((((.((((((.(...((..((((((((((.((((((((((.......(((((.((.(.((((((((((((((((...((....))...).))))))))))))))).).))..))).)).((((((.(((....))).)))))).)))))).))))..)))...((((.....)))).......(((((((...)))))))((((.((.((.(((...)))..)).)))))).(((((((.(((.((((.((........)).))))))).).)))))))))))))((((((((....))).)))))..)).)))))...)).)).)))).(((((((...)))))))......))))))))))))..).)))........(((((((((.....((....))..........((((.....(((((((((...)))).)))))..)))).................)))))))))
Thermodynamic Ensemble Prediction
,((((.{{,(((..,,(((({({{({,,{{{{{((({{{{{.{({,((.{((({{{,{(({((({((((((,.....|{{(((.((.(.((((((((((((((((...((....))...)}))))))))))))))).).))..))).||.((((((.(((....))).)))))).)))|||,||||..,,|...{{{{,,,,,)))).......(((((((...)))))))((({.{{.{{.{((,,,|}}..)),))}))),||{||||,|||,|{{{.{{,...,,..)).))))))),},,})}))})|}}))||{{{(((...,||},||}},..))))}))),,.|)})}|}})).|||||||}},||}||}|......}},}})))},,,..,.))).,,,....{((((((((.....((....))...,......((((.....(((((((((...)))).)))))..)))).................))))))))}

Transcripts

ID Sequence Length GC content
NM_199173.6 NCBI
AGGCCAGCUGAGUCCUGAGCAGCAGCCCAGCGCAGCCACCGAGACACCA… 506 nt 0.6265
Summary

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

Forensic Context

A study in humans demonstrated that the BGLAP was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption [Farris et al. DOI:10.1038/Mp.2014.159].