Basic Information

Symbol
TMEM106B
RNA class
mRNA
Alias
Transmembrane Protein 106B MGC33727 FLJ11273 HLD16
Location (GRCh38)
7:12211042-12243367
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001134232.2
Sequence length
12351.0 nt
GC content
0.3387

Transcripts

ID Sequence Length GC content
NM_001134232.2 NCBI
AGCUCUACGGCGGCCGCGCGCUCCAGGCCGGUCGCUCCACCCCCCGGCU… 12351 nt 0.3387
NM_018374.4 NCBI
AGCUCUACGGCGGCCGCGCGCUCCAGGCCGGUCGCUCCACCCCCCGGCU… 12545 nt 0.3397
Summary

Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy 16. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the TMEM106B as a member of a ubiquitin-mediated proteolysis gene co-expression module that was downregulated in subjects with methamphetamine-associated psychosis and overlapped with a previous convergent functional genomics-based study validating blood biomarkers for delusions [Breen et al. DOI:10.1038/tp.2016.67].