Basic Information

Symbol
TMEM116
RNA class
mRNA
Alias
Transmembrane Protein 116 FLJ90167
Location (GRCh38)
12:111930181-112013908
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_001193531.2
Sequence length
1534.0 nt
GC content
0.4426

Transcripts

ID Sequence Length GC content
NM_001193453.2 NCBI
AGUUCCGUUCCUGCUCCGCUUGAGGAGAAGCGCCAAGUGCGCAUGGGGA… 1429 nt 0.4437
NM_001193531.2 NCBI
AGUUCCGUUCCUGCUCCGCUUGAGGAGAAGCGCCAAGUGCGCAUGGGGA… 1534 nt 0.4426
NM_001294314.2 NCBI
AGUUCCGUUCCUGCUCCGCUUGAGGAGAAGCGCCAAGUGCGCAUGGGGA… 1751 nt 0.4517
NM_138341.3 NCBI
AGUUCCGUUCCUGCUCCGCUUGAGGAGAAGCGCCAAGUGCGCAUGGGGA… 1470 nt 0.4469
Summary

Predicted to be involved in signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in rats demonstrated that the TMEM116 is a member of a brain gene co-expression module associated with voluntary alcohol consumption [Saba et al. DOI:10.1111/Gbb.12698]. In a separate investigation using differentiated human neuronal cells, the TMEM116 was consistently differentially regulated across exposures to six different per- and polyfluorinated alkyl substances (PFAS), identifying it as a potential biomarker for neuronal PFAS toxicity [Running et al. DOI:10.1021/Acschemneuro.4C00652].