Basic Information

Symbol
TMEM119
RNA class
mRNA
Alias
Transmembrane Protein 119 OBIF Osteoblast Induction Factor
Location (GRCh38)
12:108589851-108598320
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_181724.3
Sequence length
2662.0 nt
GC content
0.5883

Transcripts

ID Sequence Length GC content
NM_181724.3 NCBI
AGGCGCCAGCCCAGAGCAGCCCCGGGCACCAGCACGGACUCUCUCUUCC… 2662 nt 0.5883
Summary

Involved in positive regulation of bone mineralization; positive regulation of osteoblast differentiation; and positive regulation of osteoblast proliferation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the TMEM119 was specifically expressed in sorted microglial populations, serving as a cell-type assay control marker to validate the purity and sensitivity of fluorescence-activated cell sorting procedures following spinal cord injury [Stewart et al. DOI:10.1186/s12974-021-02161-8]. A study in mice demonstrated that the TMEM119 mRNA levels changed following a cryolesion-induced traumatic brain injury, though the observed fold change was lower than 2.5 [Sanchis et al. DOI:10.1002/glia.23758].