This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Forensic Context
A study in mice identified the BGN as a hub gene with the largest degree of connectivity in the protein-protein interaction network of common upregulated mRNAs during fracture healing and as an upregulated targeted mRNA in the constructed miRNA regulatory network [Li et al. DOI:10.1155/2021/2866475].