Basic Information

Symbol
TMEM175
RNA class
mRNA
Alias
Transmembrane Protein 175 Endosomal/Lysosomal Proton Channel TMEM175 Potassium Channel TMEM175 HTMEM175 MGC4618 Endosomal/Lysomomal Potassium Channel TMEM175 Endosomal/Lysosomal Potassium Channel TMEM175
Location (GRCh38)
4:932168-958741
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032326.4
Sequence length
1787.0 nt
GC content
0.6323

Transcripts

ID Sequence Length GC content
NM_001297423.2 NCBI
GAACUUCCGGCUGUCAAGCUCCCGGCCGGGCUGACUCAAGCGGAGGCGC… 2248 nt 0.6379
NM_001297424.2 NCBI
GAACUUCCGGCUGUCAAGCUCCCGGCCGGGCUGACUCAAGCGGAGGCGC… 1564 nt 0.6279
NM_001297425.2 NCBI
GAACUUCCGGCUGUCAAGCUCCCGGCCGGGCUGACUCAAGCGGAGGCGC… 1561 nt 0.6278
NM_001297426.2 NCBI
GAACUUCCGGCUGUCAAGCUCCCGGCCGGGCUGACUCAAGCGGAGGCGC… 2028 nt 0.6356
NM_001297427.2 NCBI
GAACUUCCGGCUGUCAAGCUCCCGGCCGGGCUGACUCAAGCGGAGGCGC… 2284 nt 0.6384
NM_001297428.2 NCBI
GAACUUCCGGCUGUCAAGCUCCCGGCCGGGCUGACUCAAGCGGAGGCGC… 1600 nt 0.6288
NM_032326.4 NCBI
GAACUUCCGGCUGUCAAGCUCCCGGCCGGGCUGACUCAAGCGGAGGCGC… 1787 nt 0.6323
Summary

Enables arachidonate binding activity; potassium ion leak channel activity; and proton channel activity. Involved in lysosomal lumen pH elevation; potassium ion transmembrane transport; and proton transmembrane transport. Located in endosome membrane and lysosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mouse cardiac mesenchymal stem cells demonstrated that overexpression of the TMEM175 induced transcriptional reprogramming, including the downregulation of TMEM175 mRNA, which is a gene involved in lysosomal function [Zhang et al. DOI:10.3390/biom15050662].