Basic Information

Symbol
TMTC1
RNA class
mRNA
Alias
Transmembrane O-Mannosyltransferase Targeting Cadherins 1 ARG99 OLF Transmembrane And Tetratricopeptide Repeat Containing 1 Protein O-Mannosyl-Transferase TMTC1 FLJ31400 FLJ41625 Transmembrane And Tetratricopeptide Repeat Containing 1A Transmembrane And Tetratricopeptide Repeat-Containing 1 EC 2.4.1.109 TMTC1A
Location (GRCh38)
12:29500840-29784759
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001193451.2
Sequence length
8846.0 nt
GC content
0.4158

Transcripts

ID Sequence Length GC content
NM_001193451.2 NCBI
GUUUAUUUGCAGCUGGGCCAACUCCGCGGCGCAGGCGGCGGCGGAGCGC… 8846 nt 0.4158
NM_001367875.2 NCBI
GUUUAUUUGCAGCUGGGCCAACUCCGCGGCGCAGGCGGCGGCGGAGCGC… 9032 nt 0.4157
NM_175861.3 NCBI
AGAUAGAAAAAGUAGUUUGCUUGGCAUCUCCCAAAUUAUCUUGAGCAAA… 8841 nt 0.4053
Summary

Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the TMTC1 (TMTC1) as an upregulated mRNA in peripheral whole blood from sepsis patients compared to healthy controls through RNA-sequencing analysis [Qin et al. DOI:10.1097/JCMA.0000000000000209].