Basic Information

Symbol
TNC
RNA class
mRNA
Alias
Tenascin C TN HXB Glioma-Associated-Extracellular Matrix Antigen Deafness, Autosomal Dominant 56 Hexabrachion (Tenascin) Myotendinous Antigen Neuronectin GP 150-225 Cytotactin MGC167029 Tenascin DFNA56 GMEM TN-C JI Hexabrachion (Tenascin C, Cytotactin) Tenascin-C Additional Domain 1 Hexabrachion Tenascin-C 150-225 GP
Location (GRCh38)
9:115019575-115118257
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002160.4
Sequence length
8500.0 nt
GC content
0.5249

Transcripts

ID Sequence Length GC content
NM_001410991.1 NCBI
GGCCACAGCCUGCCUACUGUCACCCGCCUCUCCCGCGCGCAGAUACACG… 8058 nt 0.5222
NM_002160.4 NCBI
GGCCACAGCCUGCCUACUGUCACCCGCCUCUCCCGCGCGCAGAUACACG… 8500 nt 0.5249
Summary

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011] CIViC Summary for TNC Gene

Forensic Context

A study in rats demonstrated that the TNC was upregulated (2.5-fold) in right ventricular tissue from animals with monocrotaline-induced pulmonary arterial hypertension and right ventricular failure, where it is associated with fibrosis [Potus et al. DOI:10.3390/ijms19092730]. Another study in rats showed that the TNC was upregulated in fetal cardiac fibroblasts compared to neonatal fibroblasts, implicating its role in developmental tissue morphogenesis [Perreault et al. DOI:10.1152/physiolgenomics.00074.2021].