Basic Information

Symbol
TNFAIP3
RNA class
mRNA
Alias
TNF Alpha Induced Protein 3 OTUD7C A20 Tumor Necrosis Factor Alpha-Induced Protein 3 OTU Domain-Containing Protein 7C Putative DNA-Binding Protein A20 Zinc Finger Protein A20 Tumor Necrosis Factor, Alpha-Induced Protein 3 Tumor Necrosis Factor, Alpha Induced Protein 3 Tumor Necrosis Factor Inducible Protein A20 TNF Alpha-Induced Protein 3 EC 3.4.19.12 EC 2.3.2.- TNFA1P2 AIFBL1 AISBL
Location (GRCh38)
6:137866383-137885836
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001270508.2
Sequence length
4665.0 nt
GC content
0.4935

Transcripts

ID Sequence Length GC content
NM_001270507.2 NCBI
GCAGUCUGCAGUCUUCGUGGCGGGCCAAGCGAGCUUGGAGCCCGCGGGG… 4641 nt 0.4921
NM_001270508.2 NCBI
GCAGUCUGCAGUCUUCGUGGCGGGCCAAGCGAGCUUGGAGCCCGCGGGG… 4665 nt 0.4935
NM_006290.4 NCBI
GCAGUCUGCAGUCUUCGUGGCGGGCCAAGCGAGCUUGGAGCCCGCGGGG… 4617 nt 0.4908
Summary

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012] CIViC Summary for TNFAIP3 Gene

Forensic Context

A study in pigs demonstrated that a Partial Least Square regression model based on a 13-gene signature, including the TNFAIP3, in subcutaneous fat could predict the age of experimental bruises with a precision of approximately ±2 hours [Barington et al. DOI:10.007/s12024-017-9869-2]. In human acute myocardial infarction patients, single-cell RNA sequencing revealed that the TNFAIP3 was upregulated in CD8+ effector T cells from patients without plaque rupture, where it was associated with angiogenesis and wound healing processes [Qian et al. DOI:10.3389/fimmu.2022.908815]. A study in mice demonstrated that natural killer (NK) cells in brown adipose tissue exhibited higher transcriptional variability and a lower coefficient of determination for gene expression across aging time points (3, 18, and 24 months) compared to other cell types, indicating impaired function with aging [Brbić et al. DOI:10.1038/s41592-020-00979-3].