Basic Information

Symbol
TNFRSF10C
RNA class
mRNA
Alias
TNF Receptor Superfamily Member 10c TRAILR3 DcR1 TRID LIT CD263 Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain Tumor Necrosis Factor Receptor Superfamily Member 10C TNF-Related Apoptosis-Inducing Ligand Receptor 3 Antagonist Decoy Receptor For TRAIL/Apo-2L Decoy TRAIL Receptor Without Death Domain Lymphocyte Inhibitor Of TRAIL Decoy Receptor 1 TRAIL-R3 TRAIL Receptor Without An Intracellular Domain Cytotoxic TRAIL Receptor-3 TRAIL Receptor 3 CD263 Antigen DCR1-TNFR DCR1
Location (GRCh38)
8:23102921-23118759
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003841.5
Sequence length
1395.0 nt
GC content
0.5699

Transcripts

ID Sequence Length GC content
NM_003841.5 NCBI
GGCAGUGCAGCUGUGGGAACCUCUCCACGCGCACGAACUCAGCCAACGA… 1395 nt 0.5699
Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human epidermal keratinocytes demonstrated that the TNFRSF10C was upregulated 1.65-fold at 3 hours following a cytotoxic 5 Gy X-ray irradiation, identifying it as part of the transcriptional response to ionizing radiation-induced skin injury [Koike et al. DOI:10.1269/jrr.46.173]. In a separate investigation of thermally injured human skin, the TNFRSF10C was found to be significantly up-regulated in burned tissue compared to normal skin, classifying it within the inflammatory and immune response gene category during the early wound repair process [Greco et al. DOI:10.1016/j.burns.2009.06.211].