Basic Information

Symbol
TNFRSF10D
RNA class
mRNA
Alias
TNF Receptor Superfamily Member 10d TRAILR4 TRUNDD DcR2 CD264 Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain Tumor Necrosis Factor Receptor Superfamily Member 10D TNF-Related Apoptosis-Inducing Ligand Receptor 4 TRAIL Receptor With A Truncated Death Domain TRAIL Receptor 4 Decoy Receptor 2 TRAIL-R4 TNF Receptor-Related Receptor For TRAIL CD264 Antigen DCR2
Location (GRCh38)
8:23135588-23164027
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003840.5
Sequence length
3535.0 nt
GC content
0.4707

Transcripts

ID Sequence Length GC content
NM_003840.5 NCBI
AGUGUAGCUGCGAGAACCUUUGCACGCGCACAAACUACGGGGACGAUUU… 3535 nt 0.4707
Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human skin demonstrated that the TNFRSF10D is significantly up-regulated in thermally injured tissue compared to normal skin during the early wound repair process, as part of an extensive temporal gene expression profile involving 2,286 altered genes [Greco et al. DOI:10.1016/j.burns.2009.06.211].